D-Pyroglutamic acid

CAS No. 4042-36-8

D-Pyroglutamic acid ( (R)-(+)-2-Pyrrolidone-5-carboxylic acid )

Catalog No. M19602 CAS No. 4042-36-8

D-Pyroglutamic acid (PCA) is a cyclic derivative of glutamic acid physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 58 In Stock
1G 82 In Stock

Biological Information

  • Product Name
    D-Pyroglutamic acid
  • Note
    Research use only not for human use.
  • Brief Description
    D-Pyroglutamic acid (PCA) is a cyclic derivative of glutamic acid physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat.
  • Description
    D-Pyroglutamic acid (PCA) is a cyclic derivative of glutamic acid physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat. In clinical pharmacology experiments PCA significantly shortens the plasma half-life of ethanol during acute intoxication.
  • Synonyms
    (R)-(+)-2-Pyrrolidone-5-carboxylic acid
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4042-36-8
  • Formula Weight
    129.11
  • Molecular Formula
    C5H7NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    OC(=O)[C@H]1CCC(=O)N1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Palekar AG et al. Accumulation of 50oxo-L-proline and 5-oxo-D-proline in the blood plasma in end stage renal disease. Biochem Med. 1975 Nov;14(3):339-45.
molnova catalog
related products
  • Aminomalonic acid

    Aminomalonic acid (Ama) was first detected in alkaline hydrolysates of proteins in 1984. Ama has been isolated from proteins of Escherichia coli and human atherosclerotic plaque. The presence of Ama has important biological implications because the malonic acid moiety potentially imparts calcium binding properties to protein.

  • Elamipretide

    Elamipretide (SS-31, MTP-131, Bendavia) is a novel cell-permeable antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that targets inner mitochondrial membrane and prevents oxidative damage of neuronal cells and other cell types.

  • 7-Amino-4-methylcoum...

    7-Amino-4-methylcoumarin is more suitable as a substrate for enteropeptidase than GD(4)K-NA.