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D-Pyroglutamic acid

CAS No. 4042-36-8

D-Pyroglutamic acid ( (R)-(+)-2-Pyrrolidone-5-carboxylic acid )

Catalog No. M19602 CAS No. 4042-36-8

D-Pyroglutamic acid (PCA) is a cyclic derivative of glutamic acid physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    D-Pyroglutamic acid
  • Note
    Research use only not for human use.
  • Brief Description
    D-Pyroglutamic acid (PCA) is a cyclic derivative of glutamic acid physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat.
  • Description
    D-Pyroglutamic acid (PCA) is a cyclic derivative of glutamic acid physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat. In clinical pharmacology experiments PCA significantly shortens the plasma half-life of ethanol during acute intoxication.
  • Synonyms
    (R)-(+)-2-Pyrrolidone-5-carboxylic acid
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4042-36-8
  • Formula Weight
    129.11
  • Molecular Formula
    C5H7NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    OC(=O)[C@H]1CCC(=O)N1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Palekar AG et al. Accumulation of 50oxo-L-proline and 5-oxo-D-proline in the blood plasma in end stage renal disease. Biochem Med. 1975 Nov;14(3):339-45.
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